Supply Chain Coordination with Quantity Discount for Seasonal Demand

Coordination between manufacturers and multiple buyers represents an important problem in supply chain management. In this paper, we develop a supply chain coordination mechanism in a system with a dominant manufacturer that delivers seasonal products to a group of buyers. These buyers have common replenishment times and receive delivery through a common delivery channel. A twice-stage ordering and production system is introduced in which the first order is placed at some time in advance of the selling season and a second order is placed closer to the selling period. This reorder strategy allows the buyer to collect additional information about seasonal demand, thereby reducing demand forecast error and simultaneously smoothing out production time. This twice-stage model results in savings for both manufacturer and the buyers. Strategies for developing sustainable cooperation between manufacturers and buyers are discussed in light of the conclusions of this model

Inventory Management and Supply Chain Coordination Mechanisms

This dissertation is on inventory management and supply chain coordination mechanisms within an economic order quantity framework. Specifically, this research focuses on modeling optimal order policies and coordination mechanisms for a supply chain involving items which experience probabilistic failure during storage. These items are common types of manufactured items which, nonetheless, require specialized order policy considerations due to their unique characteristics. We first develop the solution for the buyer’s problem through the use of an economic order quantity (EOQ) model incorporating item failure. We then proceed to model the manufacturer’s problem through the use of an economic production quantity (EPQ) model. Finally, we consider mechanisms to promote mutually-beneficial cooperation between the supplier and n buyers in service of coordinating the entire supply chain. While prior research has focused on items which can be repaired or sold at a discount upon failure, such models are inappropriate for systems where repair costs exceed or are equivalent to item costs and imperfect items are unacceptable. Examples of industries featuring these inventory conditions include the medical, defense, and electronics industries where defective items are largely useless. First, our EOQ model considers a buyer-supplier relationship featuring delivery and stocking of items which experience probabilistic failure in storage. Thereafter, our EPQ model considers in-house production of such items. Collectively, our EOQ and EPQ models provide methods for developing optimal order policies necessary to achieve practicable supply chain coordination. In order to validate the necessity of the developed models, we include an empirical analysis of item reliability for some common mechanical components used in the defense industry, thereby identifying items which fail in the manner modeled in this dissertation. Having considered optimal order policies for both buyers and suppliers, we next develop an optimal solution for a coordinated supply chain. The proposed solution allows the manufacturer to coordinate a supply chain consisting of n buyers in order to achieve a common replenishment time. Through this optimization framework, we minimize total system-wide costs and derive the cost savings associated with our coordinated solution. Numerical examples are then used to demonstrate the magnitude of cost savings achievable through our coordination framework. We conclude by proposing several mechanisms for leveraging the resulting cost savings to induce mutually-beneficial cooperation between the supplier and multiple buyers. Given the lack of buyer-supplier cooperation noted in empirical research related to supply chain coordination, our identification of specific mechanisms useful for inducing mutually-beneficial cooperation between buyers and suppliers represents an important practical contribution to the supply chain coordination literature. These models are accompanied by a thorough overview and discussion of economic order quantity theory, optimal order policies, and supply chain coordination mechanisms.Ph.D., Business Administration -- Drexel University, 201

A Supply Chain Coordination Mechanism for Common Items Subject to Failure in the Electronics, Defense, and Medical Industries

Improved production processes, particularly miniaturization, have led to the development and use of non-reworkable items subject to failure in modern production environments. Coordinating supply chains for these items requires cooperation between suppliers and buyers in order to balance ordering/setup and holding costs among system partners. In this paper, we first determine optimal inventory policies for both the supplier and buyer. We then apply the bisection method to develop a mechanism which uses a common replenishment time to coordinate a supply chain consisting of a single supplier and n buyers. By utilizing this optimization framework, we minimize total system-wide costs and derive the cost savings associated with our coordinated solution. Numerical examples are then provided for illustration

The Rocket: Analyzing RTP (Return to Player), Payoff distribution and player behavior in crash games

Abstract Rocket is a crash game developed by DraftKings, an American publicly traded online casino, sports betting and fantasy sports company. DraftKings Rocket is a game played with a rising rocket. Players must exit the rocket at any point before the rocket crashes. In that case they receive the payoff in accordance to the multiplier of their exit point. If the rocket crashes before the player bails, player’s payoff is 0 (and they lose their bet). The game boasts an unprecedented 97% RTP (Return to Player). For comparison, Atlantic City casino slots typically have a 91-92% RTP, while Vegas casino slots average 92-96% RTP. We plan to answer the following questions: 1) What is the distribution of the rocket crash times? 2) How many players are on board and how many bail before the explosion? 3) What are the optimal Rocket strategies for the player? 4) Can gaming operators attract more players by offering higher RTP levels similarly to how Walmart thrives by offering Everyday low prices and passing on the value to the consumers? 5) Does player behavior differ depending on the amount of money they bet? 6) How can the behavior of Rocket players be extended to that of stock/crypto investors? Implications Statement/Target Audience: This research has significant business implications for both online and offline casinos/gaming operators, Decision Sciences Professionals, Game Theory Researchers, as well as Exchanges, Investors, Traders and Market Makers in the Securities and Cryptocurrency markets

Estimating the Effect of Poker Room Promotions on Player Traffic

This paper examines the impact of poker room promotions on player traffic in casino-based poker rooms. Casinos regularly spend significant portions of their marketing budget on promotions, including free-play, item-based offers, complementary hotel rooms, and travel reimbursements (among others), in an effort to drive casino traffic. Poker room promotions, by contrast, are unique within the context of casino promotions because they are both player-funded and paid in cash. Despite these significant differences between poker room and other casino promotions, prior research has not provided empirical evidence on the effectiveness of poker room promotions. Using collected data on casino-based poker games and poker room promotions over an eight-month period, we present an analysis investigating the impact of common types of poker room promotions on player traffic. Our research conclusively demonstrates a consistently strong positive effect of poker room promotions on player traffic. This research offers a number of important insights not only for the gaming industry, but also for other industries which make use of a variety of promotion types (e.g. retail, hospitality and tourism, etc.)

Errors in CGAP xProfiler and cDNA DGED: the importance of library parsing and gene selection algorithms

<p>Abstract</p> <p>Background</p> <p>The Cancer Genome Anatomy Project (CGAP) xProfiler and cDNA Digital Gene Expression Displayer (DGED) have been made available to the scientific community over a decade ago and since then were used widely to find genes which are differentially expressed between cancer and normal tissues. The tissue types are usually chosen according to the ontology hierarchy developed by NCBI. The xProfiler uses an internally available flat file database to determine the presence or absence of genes in the chosen libraries, while cDNA DGED uses the publicly available UniGene Expression and Gene relational databases to count the sequences found for each gene in the presented libraries.</p> <p>Results</p> <p>We discovered that the CGAP approach often includes libraries from dependent or irrelevant tissues (one third of libraries were incorrect on average, with some tissue searches no correct libraries being selected at all). We also discovered that the CGAP approach reported genes from outside the selected libraries and may omit genes found within the libraries. Other errors include the incorrect estimation of the significance values and inaccurate settings for the library size cut-off values. We advocated a revised approach to finding libraries associated with tissues. In doing so, libraries from dependent or irrelevant tissues do not get included in the final library pool. We also revised the method for determining the presence or absence of a gene by searching the UniGene relational database, revised calculation of statistical significance and sorted the library cut-off filter.</p> <p>Conclusion</p> <p>Our results justify re-evaluation of all previously reported results where NCBI CGAP expression data and tools were used.</p

Induction of Premature Senescence by Hsp90 Inhibition in Small Cell Lung Cancer

BACKGROUND: The molecular chaperone Hsp90 is a promising new target in cancer therapy and selective Hsp90 inhibitors are currently in clinical trials. Previously these inhibitors have been reported to induce either cell cycle arrest or cell death in cancer cells. Whether the cell cycle arrest is reversible or irreversible has not generally been assessed. Here we have examined in detail the cell cycle arrest and cell death responses of human small cell lung cancer cell lines to Hsp90 inhibition. METHODOLOGY/PRINCIPAL FINDINGS: In MTT assays, small cell lung cancer cells showed a biphasic response to the Hsp90 inhibitors geldanamycin and radicicol, with low concentrations causing proliferation arrest and high concentrations causing cell death. Assessment of Hsp90 intracellular activity using loss of client protein expression showed that geldanamycin concentrations that inhibited Hsp90 correlated closely with those causing proliferation arrest but not cell death. The proliferation arrest induced by low concentrations of geldanamycin was not reversed for a period of over thirty days following drug removal and showed features of senescence. Rare populations of variant small cell lung cancer cells could be isolated that had additional genetic alterations and no longer underwent irreversible proliferation arrest in response to Hsp90 inhibitors. CONCLUSIONS/SIGNIFICANCE: We conclude that: (1) Hsp90 inhibition primarily induces premature senescence, rather than cell death, in small cell lung cancer cells; (2) small cell lung cancer cells can bypass this senescence through further genetic alterations; (3) Hsp90 inhibitor-induced cell death in small cell lung cancer cells is due to inhibition of a target other than cytosolic Hsp90. These results have implications with regard to how these inhibitors will behave in clinical trials and for the design of future inhibitors in this class

Safety and Usage of C1-Inhibitor in Hereditary Angioedema: Berinert Registry Data

BackgroundThe plasma-derived, highly purified, nanofiltered C1-inhibitor concentrate (Berinert; “pnfC1-INH”) is approved in the United States for treating hereditary angioedema (HAE) attacks and in many European countries for attack treatment and short-term prophylaxis.ObjectiveThe objective of this study was to describe safety and usage patterns of pnfC1-INH.MethodsA multicenter, observational, registry was conducted between 2010 and 2014 at 30 United States and 7 European sites to obtain both prospective (occurring after enrollment) and retrospective (occurring before enrollment) safety and usage data on subjects receiving pnfC1-INH for any reason.ResultsOf 343 enrolled patients, 318 received 1 or more doses of pnfC1-INH for HAE attacks (11,848 infusions) or for prophylaxis (3142 infusions), comprising the safety population. Median dosages per infusion were 10.8 IU/kg (attack treatment) and 16.6 IU/kg (prophylaxis). Approximately 95% of infusions were administered outside of a health care setting. No adverse events (AEs) were reported in retrospective data. Among prospective data (n = 296 subjects; 9148 infusions), 252 AEs were reported in 85 (28.7%) subjects (rate of 0.03 events/infusion); 9 events were considered related to pnfC1-INH. Two thromboembolic events were reported in subjects with thrombotic risk factors. No patient was noted to have undergone viral testing for suspected blood-borne infection during registry participation.ConclusionsThe findings from this large, international patient registry documented widespread implementation of pnfC1-INH self-administration outside of a health care setting consistent with current HAE guidelines. These real-world data revealed pnfC1-INH usage for a variety of reasons in patients with HAE and showed a high level of safety regardless of administration setting or reason for use

Species-specific responses of Late Quaternary megafauna to climate and humans

Despite decades of research, the roles of climate and humans in driving the dramatic extinctions of large-bodied mammals during the Late Quaternary remain contentious. We use ancient DNA, species distribution models and the human fossil record to elucidate how climate and humans shaped the demographic history of woolly rhinoceros, woolly mammoth, wild horse, reindeer, bison and musk ox. We show that climate has been a major driver of population change over the past 50,000 years. However, each species responds differently to the effects of climatic shifts, habitat redistribution and human encroachment. Although climate change alone can explain the extinction of some species, such as Eurasian musk ox and woolly rhinoceros, a combination of climatic and anthropogenic effects appears to be responsible for the extinction of others, including Eurasian steppe bison and wild horse. We find no genetic signature or any distinctive range dynamics distinguishing extinct from surviving species, underscoring the challenges associated with predicting future responses of extant mammals to climate and human-mediated habitat change.This paper is in the memory of our friend and colleague Dr. Andrei Sher, who was a major contributor of this study. Dr Sher died unexpectedly, but his major contributions to the field of Quaternary science will be remembered and appreciated for many years to come. We are grateful to Dr. Adrian Lister and Dr. Tony Stuart for guides and discussions. Thanks to Tina B. Brandt, Dr. Bryan Hockett and Alice Telka for laboratory help and samples and to L. Malik R. Thrane for his work on the megafauna locality database. Data taken from the Stage 3 project was partly funded by Grant #F/757/A from the Leverhulme Trust, together with a grant from the McDonald Grants and Awards Fund. We acknowledge the Danish National Research Foundation, the Lundbeck Foundation, the Danish Council for Independent Research and the US National Science Foundation for financial suppor

Case study: HereWay Inc. European expansion: A facility location problem

This case study describes HereWay Inc., a fictional telecommunications company based in Guangdong, China that manufactures a popular line of smartphones called Soar. At present, HereWay is highly successful at serving its domestic markets. Despite their current local success, however, HereWay has been planning to expand into several international markets. Their initial expansion plans involved introducing their product to the United States market in order to compete with low-cost smartphones being sold by other Chinese and Korean manufacturers. The benefit of constructing local distribution will be discussed